MnDPDP: Contrast Agent for Imaging and Protection of Viable Tissue

Figure 2

MnDPDP: structure, transmetallation, and stability. In MnDPDP 3 anionic sites are balanced by 3 sodium ions. MW: MnDPDP ∼680 Da, MnPLED ∼520 Da. Transmetallation mainly by zinc (Zn²⁺) releases Mn²⁺. The enclosed table presents log conditional stability constants for metal complexes with DPDP, PLED, HSA (human serum albumin), and EDTA (ethylene-diamine tetra-acetic acid). Log values for Mn²⁺ binding to main transport proteins in plasma are also included. Material derived from [26–29].