Effect of Doxycycline on Survival in Abdominal Aortic Aneurysms in a Mouse Model

Figure 1

Overview of the experimental in vivo study design. The present experimental study included 9 ApoE/-mice, who were implanted with osmotic minipumps with subsequent release of angiotensin II and were treated in parallel with doxycycline for four weeks. After 4 weeks, mice received an MR imaging examination, which included precontrast (unenhanced) imaging (T1 TOF and IR) and postcontrast imaging (angiography, T1 map, and delayed enhancement IR). The mice were then sacrificed and histology, immunohistochemistry, and LA-ICP-MS were performed. LA-ICP-MS: laser ablation-inductively coupled plasma-mass spectrometry.