IL-10 in Antilipopolysaccharide Immunity Against Systemic <i>Klebsiella</i> Infections

Rukavina, Tomislav; Ticac, Brigita; Vasiljev, Vanja

doi:https://doi.org/10.1155/MI/2006/69431

Mediators of Inflammation

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Research Article | Open Access

Volume 2006 | Article ID 069431 | https://doi.org/10.1155/MI/2006/69431

IL-10 in Antilipopolysaccharide Immunity Against Systemic Klebsiella Infections

Tomislav Rukavina,^1,2Brigita Ticac,^1,2and Vanja Vasiljev¹

Received30 Mar 2006

Revised12 Sept 2006

Accepted18 Sept 2006

Published09 Nov 2006

Abstract

Aim. This study was undertaken in order to determine whether anti-inflammatory cytokine interleukin-10 is responsible for a previously described protection against Klebsiella infection mediated by antilipopolysaccharide antibodies. Methods. BALB/c mice were infected intraperitoneally with a lethal challenge of Klebsiella pneumoniae Caroli. One group was protected with monoclonal antibodies prior to infection and the second was not. We measured plasma levels of interleukin-10 at different time points by enzyme immunoassay and analyzed the relation between interleukin-10 and proinflammatory cytokines interleukin-6 and tumor necrosis factor-α in order to determine the association of these ratios with the outcome of infection. Major findings and conclusions. We found different pattern of interleukin-10 production in protected mice compared with unprotected ones. The difference is greatest 24 hours postinfection. The ratios between IL-10 and proinflammatory cytokines confirmed the suppressed proinflammatory response in protected animals, especially 24 hours postinfection. Hence the mortality in unprotected mice begins immediately after we conclude that such cytokine relation and IL-10 production are, at least partially, responsible for the destiny of infected animals and the outcome of infection.

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Copyright © 2006 Tomislav Rukavina et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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