Role of Bone Marrow-Derived Monocytes/Macrophages in the Repair of Mucosal Damage Caused by Irradiation and/or Anticancer Drugs in Colitis Model
Figure 2
Effect of pre- or simultaneous irradiation on the acetic acid (AA-) induced mucosal damage. (a) Mucosal damage in the colon induced by 3% AA. On the evaluated day, colon was longitudinally incised and spread. Damaged area was evaluated with stereoscopic microscope. (b) Mice were induced mucosal damage on day 0 (AA) and irradiated on the same day (AA + RT). WBC and bone marrow cells (BMC) on day 7 were indicated in the right panels. (c) Mice were AA treated (AA) or irradiated 14 days before AA treatment (AA + Pre-RT). Note that the damaged area (AA + Pre-RT) was smaller than nonirradiated control (AA), indicating that preirradiation enhanced healing of mucosal damage. WBC and BMC on day 7 were indicated in the right panels. Values represent mean ± SEM. *, **. Data were analyzed using Welch’s -test.
