Endobronchial Perfluorocarbon Reduces Inflammatory Activity before and after Lung Transplantation in an Animal Experimental Model
Figure 3
Apoptosis and inflammatory activity after lung transplantation. (a) Expression of NF-B (subunit p65) in the lung tissue after transplantation. There was an increased expression of NF-B subunit p65 in the LTx group compared with the LTx/PFC group (*). The images are representative samples of the groups. (b) Caspase 3 expression in the lung tissue after transplantation. There was a significant reduction in the expression of caspase 3 in the LTx/PFC group (*) compared with the LTx group. The images are representative samples of the groups. (c) Effect of lung transplantation on iNOS activity. iNOS activity was significantly higher in the LTx group (*). These results indicate that LTx induced the overexpression of iNOS, and the PFC treatment reduced iNOS expression. The images are representative samples of the groups. (d) Expression of nitrotyrosine in the lung tissue after transplantation. Nitrotyrosine expression was significantly lower in the LTx/PFC group compared with the LTx group (*). The images are representative samples of the groups.
