Proteinase-Activated Receptor-1 and Immunomodulatory Effects of a PAR1-Activating Peptide in a Mouse Model of Prostatitis

Figure 1

Ethanol + dinitrobenzene sulfonic acid induces inflammatory changes in wild-type mice 2 days posttreatment. Prostates were treated with sterile saline (circles) or ethanol + dinitrobenzene sulfonic acid (squares) for 1, 2, or 3 days starting on day 0. The inflammatory response was measured by monitoring (a) macroscopic prostate damage, (b) microscopic prostate damage, (c) percent prostate weight, and (d) myeloperoxidase (MPO) activity. Data are mean ± SEM of 𝑛=4–6 per point. *𝑃<0.05, **𝑃<0.01 for EtOH + DNBS versus saline; ^∧𝑃<0.05 for 2-day EtOH + DNBS versus 3-day EtOH + DNBS.

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