Proteinase-Activated Receptor-1 and Immunomodulatory Effects of a PAR1-Activating Peptide in a Mouse Model of Prostatitis

Figure 6

Instillation of the PAR1 activating peptide TFLLR-NH₂ diminishes ethanol- (EtOH-) + dinitrobenzene sulfonic acid- (DNBS-) induced microscopic damage in wild-type mice. Prostates were treated for 2 days with (a) sterile saline, (b) EtOH + DNBS (arrow indicates leukocyte recruitment, dashed arrow indicates hemorrhage, asterisk indicates acini destruction, and arrowhead indicates epithelial cell necrosis), (c) EtOH + DNBS + PAR1 activating peptide TFLLR-NH₂ (TF), and (d) EtOH + DNBS + PAR1 reverse peptide RLLFT-NH₂ (RL) (asterisk indicates acini destruction). All sections were stained with hematoxylin and eosin (H&E); original magnification 20x.

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