TGF-β3 Induces Autophagic Activity by Increasing ROS Generation in a NOX4-Dependent Pathway

Figure 1

Increasing levels of ROS and TGF-β3 in HDM-challenged mice. (a) Schematic diagram of the experimental protocol for sensitization and challenge with HDM ( mice for each group). (b) Representative confocal laser immunofluorescence photomicrography of the lung tissues in the PBS-challenged and HDM-challenged mice showed the ROS generation in the airway epithelial cells. (c) The fold change of ROS signal intensity is shown. (d) Representative images of H&E-stained lung tissue sections of PBS-challenged and HDM-challenged mice showing TGF-β3 expressions. (e) TGF-β3 in BALF was detected by ELISA. (f) The relevance between TGF-β3 and ROS generation was tested with the Pearson correlation test (). Each point is an individual mouse. Data are presented as , , and , determined by an unpaired -test.

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