The Severity of CVB3-Induced Myocarditis Can Be Improved by Blocking the Orchestration of NLRP3 and Th17 in Balb/c Mice

Figure 2

The change pattern of NLRP3-related molecules in myocardial tissue in VMC process. (a) Relative mRNA expression of NLRP3, Caspase-1, RORγt, IL-1β, IL-17, and IL-18 in heart tissues in CVB3-induced VMC. (b) IL-17 expression in heart tissue detected by IHC (original magnification ×400). (c) IL-17 expression in heart tissue acquired by IHC assay, and IOD value was calculated by Image-Pro Plus. (d, e) The protein expression of RORγt in heart tissue was detected by WB and calculated by Bio-Rad Image Lab 6.0. (f, g) The protein expression of NLRP3 in heart tissue was detected by WB and calculated by Bio-Rad Image Lab 6.0. Statistical description: ns, , , , and stand for no statistically significant difference, , , , and , respectively, for VMC group versus control group at different time points. ## and ### mean for the marked VMC group versus other VMC groups.

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