Distinct Murine Pancreatic Transcriptomic Signatures during Chronic Pancreatitis Recovery

Figure 2

RNA-seq data analysis for the CON, CP, CONR, and CPR groups. Total RNAs were prepared from the mouse pancreata as mentioned in Figure 1, and RNA-seq was performed. (a) Principal component analysis (PCA) illustrates the variance of all genes expressed within each sample and among the groups. (b) The heatmap demonstrates the expression level of the DEGs among samples. Each column is a sample, and each row is a gene. The value is the -score of normalized gene expression counts. For any given gene, the red color represents gene expression that is greater than the overall mean, and the blue color represents gene expression that is less than the overall mean. Hierarchical clustering of genes and samples is represented by the dendrograms on the left and across the top of the heatmap. For the CP and CPR groups, each could cluster as a unique group. (c) The Venn diagram depicts the distribution of the DEGs. The statistical criteria for a gene to be considered differentially expressed were a fold change of and .

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