Ellagic Acid Alleviates Rheumatoid Arthritis in Rats through Inhibiting MTA1/HDAC1-Mediated Nur77 Deacetylation

Figure 7

EA alleviated RA progression in CIA rats. Wistar rats were randomly divided into five groups ( per group): control, CIA, CIA + EA (25 mg/kg), CIA + EA (50 mg/kg), and CIA + EA (100 mg/kg). The rats were immunized by intradermally injecting the collagen emulsion to establish CIA rat model, and EA was orally administered. (a–d) The expression of MTA1, HDAC1, and Nur77 in synovial tissues of rats was measured by using Western blot analysis. (e) The arthritis index of rats in each group was detected once a week. (f) The paw swelling of rats in each group was detected once a week. (g) Effects of EA on histopathological changes in the synovial tissues of CIA rats, using HE staining. (h–j) The levels of TNF-α, IL-1β, and IL-6 in synovial tissues were examined by using ELISA. Data from at least three replicate experiments were presented as . compared with the control group; ^# and ^##, compared with the CIA group.

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