Perilla Leaf Extract Attenuates Asthma Airway Inflammation by Blocking the Syk Pathway

Figure 5

Verification that Syk, PKC, NF-κB, and cPLA₂ were related with PLE attenuated inflammation in DNP-IgE/BSA-induced RBL-2H3 cells. (a) (A) Images of RBL-2H3 cells stained by toluidine blue (magnification, ×400), (B) the percent of degranulation (%) (), (C) the release rate of β-Hex (%), and (D) the concentration of TNF-α in cells cotreated with PLE and Syk inhibitor ( independent experiments). (b) The release rate of β-Hex and (c) production of TNF-α in cells cotreated with PLE and PKC, NF-κB, or cPLA₂ inhibitor ( independent experiments). ^##vs. the control group; and vs. the model group.

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