Butyrate Inhibits Osteoclast Activity <i>In Vitro</i> and Regulates Systemic Inflammation and Bone Healing in a Murine Osteotomy Model Compared to Antibiotic-Treated Mice

<div>Butyrate regulates pathways and expression of genes relevant for bone healing and osteoclast differentiation. RNA sequencing of human osteoclast precursor cells following 6 h of butyrate treatment. (a) Volcano plot showing number of upregulated and downregulated genes in osteoclast precursor cells following 6 h stimulation with 0.5 mM butyrate. Functional enrichment analysis showing the three most significantly downregulated (b) and upregulated (c) pathways following 6 h of 0.5 mM butyrate treatment. (d) Downregulation and (e) upregulation of genes involved in osteoclast differentiation following 6 h 0.5 mM butyrate treatment. 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Mediators of Inflammation

fig2

Figure 2

Figure 2: Butyrate Inhibits Osteoclast Activity <i>In Vitro</i> and Regulates Systemic Inflammation and Bone Healing in a Murine Osteotomy Model Compared to Antibiotic-Treated Mice 

Figure 2 | Butyrate Inhibits Osteoclast Activity In Vitro and Regulates Systemic Inflammation and Bone Healing in a Murine Osteotomy Model Compared to Antibiotic-Treated Mice 