Sphingosine Kinase 1 Plays an Important Role in Atorvastatin-Mediated Anti-Inflammatory Effect against Acute Lung Injury

Figure 8

Schematic description of the potential role of SphK1 in atorvastatin-mediated anti-inflammatory effect. Under control condition, sphingosine exists as an inactive form and there is balance between the stress fiber system and the cortactin ring system. When atorvastatin is added, stress fiber is inactivated, the cortical ring is enhanced, and the VE-cadherin junction is tightened. Meanwhile, atorvastatin inhibits the MAPK signal pathway and attenuates inflammatory responses. Sphingosine kinase 1 is a mediator in these processes.