An Aptamer-Based Antagonist against the Receptor for Advanced Glycation End-Products (RAGE) Blocks Development of Colorectal Cancer

<div>Association of RAGE expression with tumor angiogenesis in colorectal cancer development. (a) HCT116 cells were intradermally injected into the upper flank of 6-week female nude mice to establish colorectal cancer xenograft model. (b) Immunohistochemical analysis of cancer tissues and the paracancer tissues from nude mice using antibodies against RAGE and p-NF<i>κ</i>B. Scale bar: 50 <i>μ</i>m. (c) Immunohistochemical analysis of cancer tissues and the paracancer tissues from nude mice using antibodies against VEGF-A and CD31. Scale bar: 50 <i>μ</i>m.</div>

Mediators of Inflammation

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Figure 1

Figure 1: An Aptamer-Based Antagonist against the Receptor for Advanced Glycation End-Products (RAGE) Blocks Development of Colorectal Cancer 