Extracellular HMGB1 Induced Glomerular Endothelial Cell Injury via TLR4/MyD88 Signaling Pathway in Lupus Nephritis

Figure 2

Glomerular endothelial glycocalyx shedding was associated with proteinuria in MRL/lpr mice. (a) Glomerular endothelial glycocalyx of mice was observed by TEM. (b, c) The level of SDC-1 and VCAM-1 in plasma of control and LN mice was measured by ELISA (). (d) Correlation analysis of plasma SDC-1 level and 24 h proteinuria in mice (, ). (e) IF of SDC-1 (red) and CD31 (green) in glomeruli of control and LN mice. (f) IHC of VCAM-1 in mouse glomeruli of control and LN groups. (g) The level of NO in the renal cortex of control and LN mice was detected (). NO: nitric oxide.

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