Smurf1 Facilitates Oxidative Stress and Fibrosis of Ligamentum Flavum by Promoting Nrf2 Ubiquitination and Degradation

Figure 5

Nrf2 is the target of Smurf1. (a) Nrf2 mRNA level in the LDH and HLF patients was assessed by qRT-PCR (). (b) Western blotting and semiquantification for Nrf2 level in the LDH and HLF patients (). . (c) qRT-PCR was used to determine the level of Nrf2 mRNA in LF cells with or without Smuf1-OE. (d) Western blotting and semiquantification for Collagen I, Collagen III, and α-SMA mRNA level in the LF cells with or without Smuf1-OE. .

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