HMGB2 Deficiency Mitigates Abdominal Aortic Aneurysm by Suppressing Ang-II-Caused Ferroptosis and Inflammation via NF-κβ Pathway

Figure 5

HMGB2 knockdown alleviated Ang-II-caused ferroptosis by activating the NF-κβ signaling. VSMCs were assigned to Ang-II, Ang-II + shHMGB2#3, Ang-II + shHMGB2#3, and Ang-II + shHMGB2#3 + Erastin groups. The protein level of IKKβ, p-IKKβ, p65, and p-p65 were measured by western blot.