circRNA_17725 Promotes Macrophage Polarization towards M2 by Targeting FAM46C to Alleviate Arthritis

Figure 5

circRNA_17725 regulated macrophage proliferation, apoptosis, and inflammation. (a) Flow cytometry: Lv-circRNA_17725 plasmids promoted the apoptosis of macrophages induced by H₂O₂ at 4 h (; ). (b) EdU: Lv-circRNA_17725 plasmids inhibited the proliferation of macrophages at 48 h (20x; ; ). (c) CCK-8: Lv-circRNA_17725 plasmids inhibited the proliferation of macrophages in a time-dependent way (; ). (d) ELISA: Lv-circRNA_17725 plasmids decreased TNF-α, IL-1β, and MMP-9 but increased IL-10 in cells cultural supernatant (, , and ; ).

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