Comparison of Inflammatory Cytokine Levels in Hepatic and Jugular Veins of Patients with Cirrhosis

Table 2

Comparison of serum cytokine levels between patients with and without CSPH in blood from jugular and hepatic veins.

	Jugular veins						p-Values
	Non-CSPH	IQR		CSPH	IQR
IL-1β, pg/ml	15.3	15.3	24.0	15.3	15.3	40.7	0.40
Int-α2, pg/ml	1.8	1.1	4.3	2.6	1.3	4.4	0.49
Int-γ, pg/ml	5.9	2.5	9.2	9.7	2.5	19.3	0.26
TNF-α, pg/ml	2.9	1.0	13.4	10.0	1.2	22.0	0.26
MCP-1, pg/ml	107.4	104.4	138.2	110.9	70.4	195.3	0.73
IL-6, pg/ml	7.2	4.4	11.4	18.1	8.2	43.9	0.03
IL-8, pg/ml	40.0	32.8	56.2	69.1	35.5	202.9	0.08
IL-10, pg/ml (IQR)	6.7	2.4	13.7	14.7	6.0	43.8	0.13
IL-12p70, pg/ml	3.4	1.4	9.0	4.1	1.4	12.2	0.49
IL-17A, pg/ml	0.2	0.2	0.5	0.5	0.2	1.7	0.12
IL-18, pg/ml	241.0	126.6	274.1	398.0	270.4	730.0	<0.01
IL-23, pg/ml	4.5	3.2	19.7	11.7	3.2	29.5	0.73
IL-33, pg/ml	28.8	15.1	109.7	43.6	9.7	117.0	0.70
	Hepatic veins
IL-1β, pg/ml	15.3	15.3	15.4	15.3	15.3	29.1	0.24
Int-α2, pg/ml	1.8	0.9	3.1	3.2	0.9	6.8	0.27
Int-γ, pg/ml	5.1	2.5	8.3	10.4	2.5	21.6	0.16
TNF-α, pg/ml	4.6	1.0	13.4	9.2	1.4	31.1	0.32
MCP-1, pg/ml	105.4	92.5	143.1	116.3	73.4	205.2	0.78
IL-6, pg/ml	6.0	3.1	9.0	17.5	7.8	41.2	0.02
IL-8, pg/ml	32.8	32.8	61.0	85.5	37.3	281.9	0.02
IL-10, pg/ml	8.0	2.7	12.0	14.0	6.7	44.9	0.13
IL-12p70, pg/ml	3.8	1.5	7.6	4.0	1.4	18.7	0.73
IL-17A, pg/ml	0.2	0.2	0.4	0.5	0.2	1.5	0.06
IL-18, pg/ml	209.2	128.8	271.1	417.7	289.8	661.4	<0.001
IL-23, pg/ml	3.6	3.2	11.9	9.6	3.2	49.8	0.27
IL-33, pg/ml	28.4	17.3	72.1	62.1	9.9	195.0	0.43

Note. Data are expressed as median with interquartile ranges (IQR). p-values were assessed by the Mann–Whitney U-test. When significance between the groups was reached, values are printed in bold. CSPH, clinical significant portal hypertension; IL, interleukin; IFN, interferon; MCP-1, monocyte chemotactic protein-1; TNF, tumor necrosis factor; CRP, C-reactive protein.