STEAP3 Affects Ovarian Cancer Progression by Regulating Ferroptosis through the p53/SLC7A11 Pathway

Figure 1

STEAP3 is highly expressed in tumors and associated with poor prognosis in ovarian cancer: (a) analysis from the GEPIA showing the expression of STEAP3 in common malignant tumors, (b) STEAP3 was generally highly expressed in ovarian cancer tissue samples, (c) patients were categorized into STEAP3 high-expression and low-expression groups according to the median. Kaplan–Meier’s survival curve of patients with high or low STEAP3 expression level, (d, e) univariate and multivariate Cox regression analysis showed the correlation between clinicopathological factors and prognosis, (f) relative mRNA expression of STEAP3 in two OC cell lines (SKOV3 and A2780) and HOSE cell line was measured using qRT-PCR, and (g, h) representative blotting of STEAP3 in different OC cell lines, and quantification of STEAP3 protein levels relative to HOSE cell line. values are expressed as the mean ± SD, n = 3. .

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