STEAP3 Affects Ovarian Cancer Progression by Regulating Ferroptosis through the p53/SLC7A11 Pathway

Figure 4

Knockdown of STEAP3 promotes ferroptosis in ovarian cancer cells through activation of p53: (a) a significant negative correlation between STEAP3 and p53 expression through bioinformatics analysis, (b) protein expression levels of p53 in SKOV3 and A2780 cells were detected by western blot, (c) expression levels of p53, STEAP3, and ferroptosis proteins in SKOV3 and A2780 cells were detected by western blot, (d) ROS levels, and (e–g) SOD activity, MDA content, and GPX content of SKOV3 cells and A2780 cells were detected according to commercial kits. Values are expressed as the mean ± SD, n = 3. .

(a)

(b)

(c)

(d)

(e)

(f)

(g)