A Protective Role of Canonical Wnt/β-Catenin Pathway in Pathogenic Bacteria-Induced Inflammatory Responses

Figure 2

Scheme shows possible mechanisms of canonical Wnt/β-catenin pathway in the regulation of pathogenic bacteria-induced inflammatory responses. The figure represents an essential role of Wnt/β-catenin signaling serving as an inflammatory suppressor via several possible mechanisms: limitation of the expression of pro-inflammatory cytokines by sequestering NF-κB c-Rel/p50 signaling [3, 35, 41, 48, 62–64], promotion of the expression of CREB- and p50/p50-dependent immunosuppressive IL-10 [55–57], and up-regulation of the expression of IL-1Ra via an ERK1/2-dependent manner [58–61].