The Impact of Raising Children with Barth Syndrome on Parental Health-Related Quality of Life and Family Functioning: Preliminary Reliability and Validity of the PedsQL™ Family Impact Module
Table 3
Mean score differences of the PedsQL FIM between the unaffected and BTHS groups.
Unadjusteda
Multivariate adjustmentb
PS-IPTW adjustmentc
Unaffected ()
BTHS ()
Mean difference (SE)
Mean difference (SE)
Mean difference (SE)
Parental HRQoL
76.67 (15.04)
61.40 (21.59)
15.27 (4.46)
.0012
16.27 (5.42)
.0039
25.65 (6.90)
.0005
Physical functioning
74.78 (16.66)
60.60 (26.29)
14.18 (5.29)
.0099
13.01 (6.39)
.0461
21.73 (9.16)
.0214
Emotional functioning
75.64 (16.66)
59.39 (21.49)
16.24 (4.50)
.0006
18.53 (5.76)
.0021
27.51 (6.16)
<.0001
Social functioning
78.20 (21.64)
61.09 (27.12)
17.10 (5.74)
.0040
19.97 (7.10)
.0066
34.91 (8.67)
.0002
Cognitive functioning
78.07 (16.04)
63.78 (25.28)
14.28 (5.09)
.0071
13.24 (6.43)
.0437
18.90 (8.59)
.0322
Communication
87.39 (15.51)
59.09 (17.25)
28.30 (3.86)
<.0001
30.13 (4.90)
<.0001
38.01 (5.20)
<.0001
Worry
85.25 (19.89)
47.72 (19.32)
37.52 (4.64)
<.0001
41.14 (5.93)
<.0001
48.32 (6.26)
<.0001
Family functioning
70.96 (19.68)
57.23 (21.45)
13.73 (4.85)
.0061
14.56 (6.16)
.0213
30.63 (6.74)
<.0001
Daily activities
69.23 (21.04)
49.74 (19.32)
19.48 (6.44)
.0038
21.21 (7.91)
.0094
41.38 (10.50)
.0002
Family relationships
72.69 (20.89)
62.53 (20.72)
10.15 (4.92)
.0429
10.01 (6.28)
.1163
21.75 (6.73)
.0021
Total score
77.65 (14.79)
58.36 (18.03)
19.29 (3.86)
<.0001
20.71 (4.86)
<.0001
31.26 (5.59)
<.0001
Note: (SD) for unaffected and BTHS; propensity score matching with inverse probability of treatment weighting (PS-IPTW); standard error (SE). aIndependent-samples -test between the unaffected and BTHS groups. bMultiple regression model controlling for the demographic characteristics listed in Table 1. cAfter applying propensity score matching with inverse probability of treatment weighting, all demographics were balanced between the unaffected and BTHS groups.
