Combined Volumetric and Density Analyses of Contrast-Enhanced CT Imaging to Assess Drug Therapy Response in Gastroenteropancreatic Neuroendocrine Diffuse Liver Metastasis

<div>The tumor volume and HU histogram changes in one of the cases. Gastroenteropancreatic neuroendocrine liver metastasis pre- and posttreatment illustrating total tumor volume and mean volumetric tumor density changes from contrast-enhanced CT images in a single tumor progression patient. GEP-NETs with liver metastasis pretreatment (a) show a pretreatment tumor volume of 45.1 cm<sup>3</sup>, whereas in (b) the posttreatment, tumor volume was 77.6 cm<sup>3</sup>. The HU histogram (c) shows a rightward shift, representing increased enhancement on posttreatment CT imaging. The tumor HU value increased from 45.7 to 57.8 HU.</div>

Contrast Media & Molecular Imaging

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Figure 3: Combined Volumetric and Density Analyses of Contrast-Enhanced CT Imaging to Assess Drug Therapy Response in Gastroenteropancreatic Neuroendocrine Diffuse Liver Metastasis 

Figure 3 | Combined Volumetric and Density Analyses of Contrast-Enhanced CT Imaging to Assess Drug Therapy Response in Gastroenteropancreatic Neuroendocrine Diffuse Liver Metastasis 