Sequential [¹⁸F]FDG-[¹⁸F]FMISO PET and Multiparametric MRI at 3T for Insights into Breast Cancer Heterogeneity and Correlation with Patient Outcomes: First Clinical Experience

Figure 1

46-year-old patient with hormone receptor positive/Her2 negative invasive ductal carcinoma in the left breast. Multiparametric [¹⁸F]FDG/[¹⁸F]FMISO PET-MRI : cancer presented as a segmental heterogenous persistently enhancing nonmass enhancement. (f–h) DCE_native, DCE_early, and DCE_delayed with perifocal edema. (a) T2-weighted without fat saturation. (b) T2-weighted with fat saturation. The lesion showed moderate uptake of (c) [¹⁸F]FDG (SUV_max = 6.5) and (d) [¹⁸F]FMISO (SUV_max = 1.3) with restricted diffusion visualized on the ADC map (e).

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