Evaluation of Myelin Radiotracers in the Lysolecithin Rat Model of Focal Demyelination: Beware of Pitfalls!

Figure 1

Comparison of MRI (T2WI, left column) and histology with Sudan black B (SBB, right column) at the injection sites. Postmortem histological staining matched in vivo MRI observations. Therefore, anatomical MRI was used to (a) manually delineate areas of demyelination showing corpus callosum loss of hypointense contrast (in red, with mirror region of interest in green), (b) identify necrosis areas with overt focal edematous hypersignal (arrow), and (c) measure the maximum width of the lateral ventricle along the mediolateral plane (red segment) as an index of ventricular dilation after LPC injection.

(a)

(b)

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