MnDPDP: Contrast Agent for Imaging and Protection of Viable Tissue

Figure 6

Therapy with MnDPDP: preclinical examples. (a) Reperfusion after AMI [10]. In anesthetized pigs MnPLED, but not MnDPDP and NaCl (placebo), infused i.v. prior to and during reperfusion reduced infarct size at the end of the experiments. Reversible ligation of left coronary artery ligation with 30 min ischemia and 120 min reperfusion (reprinted with permission from Acta Radiol). (b) Cardioprotection during chemotherapy with doxorubicin (DOX) [58]. MnPLED but not MnDPDP improved inotropy during in vitro exposure to toxic doses of DOX. Water bath model with paced left atrial preparations excised from mice after pretreatment with MnDPDP (10 μM) or MnPLED (10 μM). Groups: DOX alone; DOX + MnDPDP; DOX + MnPLED (reprinted with permission from Transl Oncol). (c) Antitumoral efficacy of doxorubicin (DOX) [58]. Human ovarian tumor (A2780) bearing nude mice were treated with repeated cycles of DOX and prior infusion of MnDPDP. At the end of the study, DOX alone (control) significantly reduced tumor volumes by about 50%. There was a tendency that MnDPDP increased the antitumoral effect of DOX (reprinted with permission from Transl Oncol).