In Vivo Evaluation of Gallium-68-Labeled IRDye800CW as a Necrosis Avid Contrast Agent in Solid Tumors

Figure 4

Biodistribution and ex vivo analysis of tumor-bearing mice injected with [68Ga]Ga-1. (a) Biodistribution of [68Ga]Ga-1 in 4T1-Luc2 tumor-bearing mice at 1.5 h postinjection; error bars indicate standard deviation, n = 4 (for tumors n = 8). (b) Fluorescence and radioactivity uptake in the dichotomized left tumor from a [68Ga]Ga-1-treated mouse 2. (c) Fluorescence uptake and TUNEL dead cell staining in a 10 µm frozen tumor section from [68Ga]Ga-1-treated mouse 4.

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