Research Article

Radiomic Features of 18F-FDG PET in Hodgkin Lymphoma Are Predictive of Outcomes

Table 3

Univariate and multivariate analyses for prognostic factors of PFS.

Features valueHR (95% CI)

Univariate analysis
 Clinical parametersGender0.17262.579 (0.6609–10.06)
Age (>30)0.21040.4514 (0.1300–1.567)
Ann Arbor stage0.05903.394 (0.9548–12.07)
Extranodal sites0.17882.398 (0.6700–8.581)
B symptoms0.27912.067 (0.5550–7.698)
BM0.02139.985 (1.363–46.78)
Bulky disease (>10 cm)0.28863.078 (0.3859–24.55)
Dmax0.000234.78 (5.206–232.4)
Chemotherapy with IFRT0.09088.589 (0.7105–103.8)
 PET variablesSUVmax0.072310.52 (0.8081–137.0)
MTV0.00169.811 (2.371–40.59)
SUV kurtosis0.03163.961 (1.129–13.90)
LZHGEGLZLM0.00138.036 (2.258–28.60)

Multivariable analysis
BM0.086
Dmax0.0483.641 (1.011–13.110)
MTV0.618
SUV kurtosis0.243
LZHGEGLZLM0.0449.007 (1.066–76.116)

Statistically significant. HR, hazard ratio; CI, confidence interval; LDH, lactate dehydrogenase; BM, bone marrow; Dmax, the distance between the two lesions that were the furthest apart; MTV, metabolic tumor volume; LZHGE, long-zone high gray-level emphasis; GLZLM, gray-level zone-length matrix.