Research Article

The Effects of Transcutaneous Acupoint Electrical Stimulation on Cancer-related Fatigue and Negative Emotions in Cancer Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Table 1

Characteristics of the included studies.

Author, yearSample size (n, T/C)Age (years) (mean ± SD or range)Gender (F/M)Cancer typeTreatment methodIntervention timeOutcome indicator (scale)Quality

Tai et al., 2020 [8]127, 62/65Metastatic cancerSurgery + chemotherapy5 daysAnxiety (SAS)B
Gao and Luo, 2019 [9]84, 42/42T: 40–74; C: 41–75T: 19/23; C: 18/24Lung cancerChemotherapy8 daysAnxiety (SAS); depression (SDS)B
Hu et al., 2019 [10]100, 50/50T: 65.24 ± 8.45; C: 64.70 ± 9.65T: 18/32; C: 18/32Lung cancerChemotherapy21 daysCRF (RPFS); anxiety (SAS); depression (SDS)B
Huang and Zhao, 2019 [11]120, 60/60T: 58.25 ± 6.91; C: 59.13 ± 7.62T: 29/31; C: 32/28UncertainSurgery + chemotherapy8 weeksCRF (RPFS); quality of life (EORTc QLQ-C30)B
Li et al., 2020 [12]108, 55/53T: 59.85 ± 10.34; C: 56.83 ± 11.06T: 28/27; C: 25/28UncertainChemotherapy5 daysCRF (RPFS); quality of life (FACT-G)B
Wu et al., 2017 [13]113, 57/56T: 58.53 ± 8.42; C: 58.52 ± 10.65T: 15/42; C: 10/46Lung cancerChemotherapy28 daysCRF (RPFS); quality of life (EORTc QLQ-C30)B
Hou et al., 2017 [3]113, 57/56T: 58.06 ± 8.42; C: 58.27 ± 10.57T: 15/42; C: 10/46Lung cancerChemotherapy28 daysCRF (RPFS)B
Sun, 2011 [4]60, 30/30T: 58.0 ± 6.1; C: 57.4 ± 6.9T: 16/14; C: 18/12Gastrointestinal cancerChemotherapy7 daysCRF (RPFS)B
Hu et al., 2017 [14]113, 51/62T: 59.98 ± 8.51; C: 58.81 ± 10.50T: 15/36; C: 11/51Lung cancerChemotherapy28 daysAnxiety (SAS)A

Undetermined in cancer type refers to the original literature indicating the inclusion of patients with unspecified tumor types. Full compliance with the risk of bias in the Cochrane RCTs is grade “A” (high-quality), and partial compliance with the original studies is grade “B” (moderate quality). T, interventional group; C, control group; F, female, M, male; CRF, cancer-related fatigue; RCT, randomized controlled trial; SAS, Self-rating Anxiety Scale; RPFS, Revised Piper Fatigue Scale; SD, standard deviation; SDS, Self-rating Depression Scale; EORTc QLQ-C30, European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30.