Biliary Drainage Reduces Intestinal Barrier Damage in Obstructive Jaundice by Regulating Autophagy

Figure 6

Effects of autophagy agonist and inhibitor on intrabiliary drainage on oxidative stress in the intestinal mucosal cells of obstructive jaundice model rats. (a) Serum ROS, (b) MDA, (c) H₂O₂, and (d) GSH levels, (e) tissue ROS, (f) tissue MDA, (g) tissue H₂O₂, and (h) tissue GSH levels. Data are expressed as means ± SEM (n = 10). BDL: bile duct ligation; ID: internal drainage; IDR: internal drainage + rapamycin; ID3-MA: internal drainage  +  3-methyladenine; ROS: reactive oxygen species; MDA: malondialdehyde; H₂O₂: hydrogen peroxide; GSH: glutathione. a: P < 0.05 vs. BDL. b: P < 0.05 vs. ID. c: P < 0.05 vs. IDR.

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