The Predictive Value of Changes in the Absolute Counts of Peripheral Lymphocyte Subsets for Progression and Prognosis in Breast Cancer Patients

Table 3

Univariate and multivariate analysis of prognostic factors of PFS.

Characteristics		Univariate		Multivariate
		HR (95% CI)	value	HR (95% CI)	value
Age	<64	1 [reference]	0.583
	≥64	0.908 (0.642–1.282)
Family history	No	1 [reference]	<0.001	1.106 (0.760–1.609)	0.600
	Yes	1.969 (1.384–2.801)
Previous medical history	No	1 [reference]	0.002	1.064 (0.552–2.050)	0.854
	Yes	2.667 (1.436–4.953)
Smoking	No	1 [reference]	0.051
	Yes	1.511 (0.999–2.285)
Drink	No	1 [reference]	0.835
	Yes	0.952 (0.602–1.507)
Age of menarche	<12	1 [reference]	0.027	1.019 (0.709–1.466)	0.917
	≥12	1.482 (1.046–2.101)
Menopause	No	1 [reference]	0.301
	Yes	1.368 (0.775–2.480)
Tumor size	<2 cm	1 [reference]	0.014	0.960 (0.606–1.520)	0.861
	≥2 cm	1.716 (1.115–2.640)
Pathological category	ILC	1 [reference]	0.004	0.599 (0.273–1.316)	0.202
	IDC	2.834 (1.381–5.813)
ER	Negative	1 [reference]	0.198
	Positive	0.796 (0.562–1.127)
PR	Negative	1 [reference]	0.350
	Positive	0.848 (0.599–1.199)
Her2	Negative	1 [reference]	0.979
	Positive	1.005 (0.694–1.456)
Differentiation	High	1 [reference]	0.263
	Medium/low	1.271 (0.835–1.934)
Clinical stages	I + II	1 [reference]	<0.001	5.543 (1.845–16.650)	0.002
	III + IV	15.425 (7.796–30.521)
Lymphatic metastasis	No	1 [reference]	<0.001	1.307 (0.486–3.521)	0.596
	Yes	10.563 (5.516–20.228)
Distant metastasis	No	1 [reference]	<0.001	1.852 (1.078–3.180)	0.026
	Yes	7.497 (4.856–11.572)
Vessel carcinoma embolus	No	1 [reference]	<0.001	1.425 (0.953–2.131)	0.143
	Yes	3.797 (2.642–5.457)
Treatment	Surgery	1 [reference]	0.403
	Surgery + chemotherapy	0.840 (0.559–1.263)
	Surgery + endocrinotherapy	0.748 (0.486–1.151)	0.186
CD3^+AC (cells/μL)	<924	1 [reference]	0.862
	≥924	1.031 (0.730–1.457)
CD4^+AC (cells/μL)	<451	1 [reference]	<0.001	0.431 (0.267–0.697)	0.001
	≥451	0.170 (0.112–0.257)
CD8^+AC (cells/μL)	<324	1 [reference]	0.001	0.623 (0.426–0.913)	0.015
	≥324	0.548 (0.385–0.781)
B AC (cells/μL)	<155	1 [reference]	<0.001	0.955 (0.644–1.415)	0.817
	≥155	0.493 (0.345–0.703)
NK AC (cells/μL)	<162	1 [reference]	<0.001	1.021 (0.677–1.539)	0.922
	≥162	0.425 (0.295–0.611)

Notes: AC, absolute count; ER, estrogen receptor; PR, progesterone receptor; Her2, human epidermal growth factor receptor 2.