In silico Prediction of Deleterious Single Nucleotide Polymorphism in S100A4 Metastatic Gene: Potential Early Diagnostic Marker

Table 2

Prediction of the effect of nsSNPs on protein stability by I-MUTANT 2.0.

SNP ID	Amino acid substitution	I-mutant	DDG	RI
rs116208483	L62V	Decrease	1.75	8
rs147390231	T39I	Decrease	1.09	5
rs148291612	F72V	Decrease	−3.56	9
rs199505533	G92V	Decrease	−0.83	2
rs200099267	E74G	Decrease	−1.65	6
rs368160023	E88K	Decrease	−0.82	7
rs373367471	L5P	Decrease	−1.152	7
rs377093845	D25E	Decrease	0.05	1
rs536309763	N65S	Decrease	−0.88	8
rs566299932	A8V	Decrease	−0.07	2
rs566299932	A8D	Decrease	−1.12	4
rs576307674	R40W	Decrease	0.20	3
rs747430747	S20L	Decrease	−1.05	1
rs747868513	V70A	Decrease	−2.17	9
rs751051544	E88G	Decrease	−0.74	6
rs754093018	K57E	Decrease	−0.43	5
rs759858655	L58P	Decrease	−0.43	8
rs762009722	A8S	Decrease	−0.82	8
rs762542639	L62P	Decrease	−2.32	7
rs762597174	D92V	Decrease	0.76	2
rs766589410	F89I	Decrease	−1.04	8
rs772235092	E69L	Decrease	0.08	4
rs868262406	K26N	Decrease	0.16	1
rs899447674	F72L	Decrease	−2.52	8