In silico Prediction of Deleterious Single Nucleotide Polymorphism in S100A4 Metastatic Gene: Potential Early Diagnostic Marker

Table 3

Mutational effects on the structure and conservation of the S100A4 protein.

S.No	Mutation	Structure	Conservation
rs116208483	L62V	EF-hand -2	Not conserved
rs147390231	T39I	EF-hand 1	Not conserved
rs148291612	F72V	EF-hand domain	Located near a highly conserved protein
rs199505533	G92V	Surface of the domain	Not conserved
rs200099267	E74G	Surface of the domain	Conserved
rs368160023	E88K	Surface of the domain	Not conserved
rs373367471	L5P	Surface of the domain	Conserved
rs377093845	D25E	EF-hand 1	Very conserved
rs566299932	A8V	EF-hand domain	Very conserved
rs566299932	A8D	Surface of the domain	Very conserved
rs576307674	R40W	EF-hand 1	Not conserved
rs747430747	S20L	EF-hand 1	Very conserved
rs747868513	V70A	EF-hand 2	Very conserved
rs754093018	K57E	EF-hand 2	Conserved
rs759858655	L58P	EF-hand 2	Not conserved
rs766589410	F89I	EF domain hand pair	Very conserved
rs868262406	K26N	EF-hand 1	Very conserved
rs762542639	L62P	EF-hand 2	Very conserved
rs536309763	N65S	EF-hand 2	Very conserved
rs751051544	E88G	EF-hand 2	Not conserved
rs762542639	L62P	EF-hand 2	Very conserved
rs762597174	D92V	Present in turn	Not conserved
rs772235092	E69L	EF-hand 2	Very conserved
rs899447674	F72L	EF-hand 2	Not conserved
rs147390231	T39I	EF-hand 1	Not conserved