¹⁸F-FDG PET/CT for Identifying the Potential Primary Diseases and Predicting Prognosis of Secondary Hemophagocytic Lymphohistiocytosis in Children

Figure 2

¹⁸F-FDG PET/CT maximum intensity of sHLH in 4 children. Non-Hodgkin’s lymphoma (a), CAEBV (b), EBV-HLH (c, d), presenting as hepatosplenomegaly and increased FDG uptake of the spleen (a–d) and liver (a, c). (a) A 2-year-old girl with multiple enlarged lymph nodes (SUVmax:4.81) and multiple hypermetabolic lesions in extranodal organs, including brain, lungs, liver, and kidney (SUVmax:11.50). The child died three months later after admission. (b) A 3-year-old girl with multiple small lymph nodes (SUVmax:1.68, which was lower than the liver) slightly increased FDG uptake in the bone marrow (SUVmax:1.77). The children survived until the end of follow-up after hematopoietic stem cell transplantation. (c) A 14-year-old boy with focus and defusing increased FDG uptake in the bone marrow (SUVmax:11.13). He died of multiple organ failure. (d) A 2-year-old boy with slightly increased FDG uptake (SUVmax:2.1) in the bone marrow was slightly lower than the liver. He was still alive until the end of the follow-up.