Research Article
18F-FDG PET/CT for Identifying the Potential Primary Diseases and Predicting Prognosis of Secondary Hemophagocytic Lymphohistiocytosis in Children
Table 1
Clinical manifestations and laboratory results.
| | Items | Data | Reference |
| | Clinical manifestations | Number (percent) | | | Fever | 66 (100.0%) | — | | Hepatomegaly | 43 (65.1%) | — | | Splenomegaly | 55 (84.8%) | — | | Hemophagocytosis (bone marrow) | 45 (68.2%) | — | | Laboratory examination | Median (range) | | | Absolute neutrophil count (109/L) | 0.98 (0.18–14.59) | 1.2–7.0 | | Platelet (109/L) | 102.5 (1–319) | 100.0–300.0 | | Hemoglobin (g/L) | 93.5 (57–130) | 110–160 | | Fibrinogen (g/L) | 1.8 (0.55–4.91) | 2.0–4.0 | | Serum ferritin (ng/mL) | 1425.55 (13.20–139139.00) | 6.00–159.00 | | Triglyceride (mmol/L) | 2.54 (0.73–6.48) | 0.40–1.70 | | sCD25 (pg/mL) | 23407 (165–218875) | ＜6400 | | NK cell activity (%) | 15.74 (8.31–26.59) | ＜15.10 | | EBV-DNA (whole blood) (×105Copies/mL) | 1.23 (0.005–245) | <5 × 102 | | EBV-DNA (plasma) (×103Copies/mL) | 2.22 (0.50–7280.00) | <5 58102 | | IFN-γ (pg/mL) | 20.10 (0.00–2703.98) | 1.60–17.30 | | TNF-α (pg/mL) | 0.90 (0.00–51.59) | 1.60–17.30 | | IL-6 (pg/mL) | 24.78 (1.98–2500.00) | 1.70–16.60 | | IL-10 (pg/mL) | 29.49 (0.00–744.71) | 2.60–4.90 |
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sCD25: soluble cluster of differentiation 25; NK: natural killer; EBV: Epstein–Barr virus; IFN: interferon; TNF: tumor necrosis factor; and IL: interleukin.
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