Identification of Hub Genes and Key Pathways Associated with Follicular Lymphoma

Table 1

Considerably enriched GO terms of Hub Genes.

GO ID	Term	P value	FDR	Genes
Biological process
GO:0006955	Immune response	6.07E-07	4.25E-05	CXCL9, CXCL12, CD8A, CCL5, IL18, CCL2, CCR5
GO:0030198	Extracellular matrix organization	3.78E-07	3.53E-05	COL3A1, POSTN, VCAM1, SPARC, COL1A2, FN1
GO:0006954	Inflammatory response	9.66E-06	4.51E-04	CXCL9, CXCL12, CCL5, IL18, CCL2, CCR5
GO:0060326	Cell chemotaxis	1.99E-07	3.53E-05	CXCL9, CXCL12, VCAM1, CCL5, CCL2
GO:0070098	Chemokine-mediated signaling pathway	2.84E-07	3.53E-05	CXCL9, CXCL12, CCL5, CCL2, CCR5
GO:0006935	Chemotaxis	2.51E-06	1.41E-04	CXCL9, CXCL12, CCL5, CCL2, CCR5
GO:0007155	Cell adhesion	4.44E-04	0.00730519	POSTN, CXCL12, VCAM1, FN1, CCL2
GO:0007186	G protein-coupled receptor signaling pathway	0.005304452	0.047911184	CXCL9, CXCL12, CCL5, CCL2, CCR5
Cellular component
GO:0005615	Extracellular space	2.01E-12	9.24E-11	POSTN, CXCL9, VCAM1, SPARC, IL18, FN1, MMP9, COL3A1, CXCL12, COL1A2, CCL5, CCL2, TIMP1
GO:0005576	Extracellular region	7.02E-10	1.61E-08	COL3A1, CXCL9, CXCL12, SPARC, COL1A2, CD8A, CCL5, IL18, FN1, CCL2, TIMP1, MMP9
GO:0070062	Extracellular exosome	0.013159982	0.075669898	CXCL12, VCAM1, COL1A2, IL18, FN1, TIMP1, MMP9
GO:0005578	Proteinaceous extracellular matrix	1.19E-06	1.82E-05	POSTN, SPARC, COL1A2, FN1, TIMP1, MMP9
GO:0009897	External side of plasma membrane	1.66E-05	1.91E-04	CXCL9, CXCL12, VCAM1, CD8A, CCR5
Molecular function
GO:0005515	Protein binding	0.040126286	0.137098144	COL3A1, POSTN, CXCL9, SPARC, COL1A2, CD8A, CCL5, IL18, FN1, TIMP1, CCR5, MMP9

FDR, false discovery rate; GO, gene ontology; ID, identity document.