Lymph Node Metastases Detection Using Gd₂O₃@PCD as Novel Multifunctional Contrast Imaging Agent in Metabolic Magnetic Resonance Molecular Imaging

Figure 3

(a) T₁−weighted images of Gd2O3@CD NPs and Dotarem at various Gd concentrations.^. (b) T₁−mapping of (a). (c) R₁ (1/T1) diagram of (a), showing r₁ (mM⁻¹·s⁻¹); the slope of R₁ vs. concentration, as specific relaxivities of 3.98 and 2.71 mM⁻¹·s⁻¹ for Gd₂O₃@CD NPs and Dotarem, respectively, show efficiently shorten T₁ values of Gd₂O₃@PCD NPs leading to significantly increased signal intensity in T₁W images compared to Dotarem even in low concentrations of Gd₂O₃@PCD NPs nanoparticles in MRI.

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