Curcumin Elevates microRNA-183-5p via Cathepsin B-Mediated Phosphatidylinositol 3-Kinase/AKT Pathway to Strengthen Lipopolysaccharide-Stimulated Immune Function of Sepsis Mice

Figure 1

Cur constrains the inflammatory response of sepsis mice and strengthens its immune function. (a) AST, ALT, BUN, and creatinine in the serum; (b) contents of inflammatory factors (TNF-α, IL-1β, IL-6); (c) flow cytometry detection of percentage of CD39⁺ Tregs; (d) HE staining test of glomerular injury, dilatation of renal tubules, inflammatory cell infiltration, and vascular congestion in mice; (e) TUNEL staining detection of the apoptosis index of the liver and kidney tissue in mice; (f) RT-qPCR examination of miR-183-5p. The data in the figure are all measurement data, and each value represents the mean ± SD of 6 mice. vs. the Sham, (P) < 0.05; ^#vs. the LPS, (P) < 0.05.

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