Curcumin Elevates microRNA-183-5p via Cathepsin B-Mediated Phosphatidylinositol 3-Kinase/AKT Pathway to Strengthen Lipopolysaccharide-Stimulated Immune Function of Sepsis Mice

Figure 3

MiR-183-5p negatively modulates CTSB. (a) Starbase database prediction of the binding site of miR-183-5p with CTSB; (b-c) RT-qPCR and western blot detection of CTSB; (d) the luciferase activity assay verification of the targeting of miR-183-5p with CTSB; (e) RIP experiment validation of the targeting of miR-183-5p with CTSB. The data in the figure are all measurement data, and each value represents the mean ± SD of 6 individuals. Vs. the Sham, (P) < 0.05; ^#vs. the LPS, (P) < 0.05; vs. the agomir NC, (P) < 0.05.

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