Curcumin Elevates microRNA-183-5p via Cathepsin B-Mediated Phosphatidylinositol 3-Kinase/AKT Pathway to Strengthen Lipopolysaccharide-Stimulated Immune Function of Sepsis Mice

Figure 4

Silence of CTSB is available to further boost the protection of Cur. (a) RT-qPCR and western blot detection of CTSB; (b) AST, ALT, BUN, and creatinine in the serum; (c) contents of inflammatory factors (TNF-α, IL-1β, IL-6); (d) flow cytometry test of percentage of CD39 + Tregs; (e) HE staining examination of tissue injury; (f) TUNEL staining detection of apoptosis indexes. The data in the figure are all measurement data, and each value represents the mean ± SD of 6 individuals. vs. the si-NC, (P) < 0.05.

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