The Value of Brain Structural Magnetic Resonance Imaging Combined with APOE--ε4 Genotype in Early Diagnosis and Disease Progression of Senile Vascular Cognitive Impairment No Dementia

Table 4

Single-factor and multivariate logistic regression analysis of VCIND-related risk factors.

Features	Single factor		Multivariate
	OR (95% CI)	P-value	OR (95% CI)	P-value
Age	1.011 (0.981–1.041)	0.481
Gender	0.746 (0.387–1.437)	0.380
BMI	1.021 (0.940–1.108)	0.625
Years of education	0.645 (0.498–0.834)	0.001	0.696 (0.456–1.061)	0.092
Stroke onset time	0.931 (0.778–1.114)	0.434
Hypertension	2.333 (1.195–4.557)	0.013	2.066 (0.592–7.204)	0.255
Diabetes	1.779 (0.862–3.669)	0.119
Coronary heart disease	1.098 (0.489–2.467)	0.821
Smoking history	1.367 (0.597–3.131)	0.460
Drinking history	1.316 (0.643–2.693)	0.453
Fasting blood glucose	1.055 (0.754–1.478)	0.754
Triglycerides (TG)	1.130 (0.747–1.709)	0.560
Cholesterol (TC)	1.369 (0.945–1.984)	0.096
High-density lipoprotein (HDL)	0.524 (0.156–1.765)	0.297
Low-density lipoprotein (LDL)	1.145 (0.820–1.600)	0.427
Homocysteine (hcy)	4.125 (1.903–8.941)	0.000	5.026 (1.198–21.089)	0.027
White matter volume (WMV)	1.843 (1.438–2.361)	0.000	1.549 (1.072–2.240)	0.020
White matter hyperintensity (WMH)	8.947 (3.448–23.219)	0.000	5.199 (1.261–21.44)	0.023
Lacunar infarction (LI)	2.013 (1.118–3.623)	0.020	1.823 (0.583–5.705)	0.302
Fazekas score	5.473 (3.376–8.874)	0.000	4.631 (2.615–8.203)	≤0.001
Leukoaraiosis region
Frontal region (reference group)	1.000
Parieto-occipital region	0.700 (0.235–2.087)	0.522
Temporal region	1.350 (0.482–3.783)	0.568
Basal ganglia region	0.780 (0.354–1.717)	0.536
Cerebral atrophy	2.129 (1.063–4.265)	0.033	2.882 (0.780–10.647)	0.112
ε4 gene carrier	3.029 (1.192–7.700)	0.020	6.150 (1.164–32.482)	0.032