The Value of Brain Structural Magnetic Resonance Imaging Combined with APOE--ε4 Genotype in Early Diagnosis and Disease Progression of Senile Vascular Cognitive Impairment No Dementia
Table 5
Single-factor and multivariate logistic analysis of risk factors related to dementia.
Features
Single factor
Multivariate
HR (95% CI)
P-value
HR (95% CI)
P-value
Age
0.974 (0.943–1.007)
0.118
Gender
1.638 (0.790–3.396)
0.185
BMI
1.040 (0.949–1.140)
0.397
Years of education
0.913 (0.691–1.206)
0.521
Stroke onset time
0.943 (0.781–1.140)
0.545
Hypertension
0.699 (0.330–1.480)
0.349
Diabetes
0.979 (0.462–2.073)
0.956
Coronary heart disease
0.399 (0.121–1.318)
0.132
Smoking history
1.336 (0.592–3.017)
0.486
Drinking history
1.941 (0.936–4.024)
0.075
Fasting blood glucose
0.916 (0.618–1.358)
0.662
Triglycerides (TG)
1.503 (0.903–2.500)
0.117
Cholesterol (TC)
1.107 (0.708–1.731)
0.657
High-density lipoprotein (HDL)
1.714 (0.446–6.590)
0.433
Low-density lipoprotein (LDL)
0.691 (0.465–1.027)
0.067
Homocysteine (hcy)
0.862 (0.416–1.786)
0.690
White matter volume (WMV)
1.329 (1.129–1.564)
0.001
1.280 (1.073–1.528)
0.006
White matter hyperintensity (WMH)
2.742 (1.413–5.322)
0.003
3.044 (1.512–6.129)
0.002
Lacunar infarction (LI)
1.946 (0.804–4.709)
0.140
Fazekas score
1.841 (1.150–2.947)
0.011
1.984 (1.231–3.198)
0.005
Leukoaraiosis region
Frontal region (reference group)
1.000
Parieto-occipital region
0.953 (0.258–3.520)
0.942
Temporal region
1.052 (0.374–2.957)
0.923
Basal ganglia region
0.971 (0.402–2.343)
0.948
Cerebral atrophy
0.633 (0.288–1.391)
0.255
ε4 gene carrier
3.267 (1.575–6.776)
0.001
2.442 (1.115–5.35)
0.026
Carriage of the APOE-ε4 gene is associated with survival in patients with VCIND.
