Assessment of Antioxidant Enzyme Superoxide Dismutase (SOD) in Oral Cancer: Systematic Review and Meta-Analysis

Table 3

The SOD enzyme level changes in different biosamples of patients in various clinical stages of OSCC.

Author	Samples		Stage I	Stage II	Stage III	Stage IV	Measure	Stat Sig	Stage
	Type	Size	Mean ± SD	Mean ± SD	Mean ± SD	Mean ± SD	Unit	P-value	Criteria
Manoharan et al. [21]	Pl	48	—	3.61 ± 0.72	3.2 ± 0.17	2.99 ± 0.17	U^a/ml	<0.01	UICC
	Er	48	—	2.08 ± 0.08	1.92 ± 0.13	1.73 ± 0.09	U^a/mg Hb	<0.01	UICC
Patel et al. [26]	Er	126	1927.15 ± 203.9		2119.5 ± 115.0		U/mg Hb	In sig	AJCC
Srivastava et al. [30]	Pl	20	—	1.52 ± 0.08	1.44 ± 0.13	1.43 ± 0.1	U^a /mg Hb	In sig	TNM
Singh et al. [39]	Sa	50	0.017 ± 0.014	0.037 ± 0.019	0.019 ± 0.008	0.030 ± 0.036	U/mg	0.548	TNM
Srivastava et al. [46]	Ti	20	—	14.8 ± 0.48	14.27 ± 0.4	13.97 ± 0.8	U^a /mg Hb	In sig	TNM
Banerjee et al. [47]	Mi	30	—	46.16 ± 0.88	16.55 ± 0.48	72.7 ± 1.29	—	—	TNM
Author	Type	Size	T1; Mean ± SD	T2; Mean ± SD	T3; Mean ± SD	T4; Mean ± SD	Unit	P value	Criteria
Babiuch et al. [52]	Sa	20	8.89 ± 8.68	6.08 ± 4.61	5.71 ± 3.79	11.1 ± 3.14	U^b/ml	0.56	T Stage

OSCC-oral squamous cell carcinoma, Stat Sig-statistical significance, SD-standard deviation, Pl-plasma, Er-erythrocyte, Ti-tissue, Sa-saliva, and Mi-mitochondria. ^aThe amount of enzyme required for 50% inhibition of the formation of NADH-phenazine methosulfate NBT formazan at 520 nm. ^bThe amount of enzyme necessary to inhibit 50% epinephrine autoxidation.