Functional Analysis of DNMT1 SNPs (rs2228611 and rs2114724) Associated with Schizophrenia

Table 1

Analysis of rs2114724 and rs2228611 polymorphisms in controls and schizophrenia patients.

SNP	Genotype	Present study				Saradalekshmi et al. [9]		Combined
		Controls	Patients	Odds ratio (CI)	value	Controls	Patients	Controls	Patients	Odds ratio (CI)	Bonferroni-corrected value	Penetrance (CI)
rs2114724	C/C	98 (0.32)	105 (0.35)	1.14 (0.81–1.6)	0.44	98 (0.33)	97 (0.30)	196 (0.32)	202 (0.32)	1.00 (0.79–1.27)	1.000	—
	C/T	158 (0.51)	125 (0.41)	0.67 (0.49–0.93)	0.01	160 (0.53)	147 (0.45)	318 (0.52)	272 (0.43)	0.70 (0.56–0.88)	0.004	—
	T/T	54 (0.17)	74 (0.24)	1.52 (1.03–2.26)	0.04	43 (0.14)	81 (0.25)	97 (0.16)	155 (0.25)	1.73 (1.31–2.29)	0.0002	0.011 (0.008–0.015)
rs2228611	C/C	107 (0.35)	100 (0.33)	0.93 (0.66–1.3)	0.73	113 (0.38)	97 (0.30)	220 (0.36)	197 (0.32)	0.81 (0.64–1.03)	0.164	—
	C/T	147 (0.47)	121 (0.39)	0.73 (0.53–1.01)	0.07	152 (0.51)	155 (0.49)	299 (0.49)	276 (0.44)	0.82 (0.65–1.02)	0.14	—
	T/T	56 (0.18)	83 (0.28)	1.7 (1.16 to 2.50)	0.007	34 (0.11)	68 (0.21)	90 (0.15)	151 (0.24)	1.83 (1.37–2.44)	<0.0002	0.011 (0.008–0.016)

The major and minor alleles for rs2114724 and rs2228611 are C and T, respectively. CI: confidence interval. Underlined values indicate that the genotypes occur at high frequencies in controls than in patients. values in bold indicate that the genotypes occur at high frequencies in patients than in controls. The total number of controls in the present and previous studies was 310 and 301, respectively, whereas the number of patients was 304 and 325, respectively.