Functional Analysis of DNMT1 SNPs (rs2228611 and rs2114724) Associated with Schizophrenia
Table 3
Haplotype analysis of alleles atrs2114724 and rs2228611 in controls and schizophrenia patients.
Haplotype (rs2114724–rs2228611)
Controls
Patients
Odds ratio (CI)
value
Penetrance (CI)
(C/C) ---- (C/C)
96 (0.31)
97 (0.32)
1.04 (0.74–1.46)
0.86
—
(C/C) ---- (C/T)
2 (0.01)
8 (0.03)
4.16 (0.88–19.76)
0.06
—
(C/C) ---- (T/T)
0 (0.00)
0 (0.00)
—
—
—
(C/T) ---- (C/C)
11 (0.04)
3 (0.01)
0.27 (0.08–0.98)
0.06
—
(C/T) ---- (C/T)
145 (0.47)
113 (0.37)
0.67 (0.49–0.93)
0.01
—
(C/T) ---- (T/T)
2 (0.01)
9 (0.03)
4.70 (1.01–21.92)
0.04
0.025 (0.005–0.182)
(T/T) ---- (C/C)
0 (0.00)
0 (0.00)
—
—
—
(T/T) ---- (C/T)
0 (0.00)
0 (0.00)
—
—
—
(T/T) ---- (T/T)
54 (0.17)
74 (0.24)
1.52 (1.03–2.26)
0.04
0.01 (0.006–0.016)
Underlined values indicate that the frequency of the haplotype is significantly higher in controls than in patients. values in bold indicate that the haplotypes are significantly higher in patients than in controls. CI: confidence interval.
