Genetics Research

Research Article

Association between the PLTP rs4810479 SNP and Serum Lipid Traits in the Chinese Maonan and Han Populations

Table 6

Relationship between serum lipid parameters and relative factors in the males and females of the Han and Maonan populations.


Lipid	Risk factor	B	Std. error	Beta	t

Maonan/male

TC	Weight	0.029	0.005	0.332	5.320	<0.001
	Glucose	0.103	0.041	0.151	2.527	0.012
	Pulse pressure	−0.010	0.003	−0.190	−2.831	0.005
	Age	0.010	0.004	0.161	2.276	0.024

TG	Waist circumference	0.054	0.008	0.401	6.975	<0.001
	Glucose	0.179	0.054	0.191	3.321	0.001
	Alcohol consumption	0.365	0.142	0.148	2.574	0.011

HDL-C	Waist circumference	−0.015	0.002	−0.353	−6.195	<0.001
	Alcohol consumption	0.170	0.044	0.221	3.883	<0.001
	Genotype	−0.134	0.057	−0.133	−2.348	0.020

LDL-C	Weight	0.024	0.005	0.310	4.954	<0.001
	Alcohol consumption	−0.203	0.095	−0.128	−2.123	0.035
	Pulse pressure	−0.010	0.003	−0.212	−3.143	0.002
	Age	0.009	0.004	0.164	2.297	0.022

ApoA1	Alcohol consumption	0.153	0.031	0.293	4.898	<0.001
	Waist circumference	−0.005	0.002	−0.186	−3.231	0.001
	Cigarette smoking	0.085	0.031	0.162	2.713	0.007

ApoB	Waist circumference	0.005	0.002	0.234	2.342	0.020
	Glucose	0.025	0.008	0.183	3.254	0.001
	Pulse pressure	−0.002	0.001	−0.200	−3.164	0.002
	Age	0.002	0.001	0.179	2.638	0.009
	Weight	0.004	0.002	0,242	2.319	0.021

ApoA1/ApoB	Waist circumference	−0.021	0.004	−0.343	−6.021	<0.001
	Alcohol consumption	0.301	0.064	0.267	4.691	<0.001
	Systolic blood pressure	0.003	0.001	0.131	2.313	0.022

Maonan/female
TC	Age	0.019	0.004	0.271	5.469	<0.001
	Waist circumference	0.024	0.006	0.197	3.997	<0.001
	Glucose	−0.085	0.042	−0.102	−2.035	0.043

TG	Waist circumference	0.033	0.004	0.357	7.518	<0.001
TG	Age	0.008	0.003	0.143	3.009	0.003

HDL-C	Waist circumference	−0.014	0.002	−0.288	−5.861	<0.001
HDL-C	Genotype	−0.100	0.050	−0.098	−1.992	0.047

LDL-C	Age	0.013	0.003	0.235	4.870	<0.001
	Waist circumference	0.020	0.005	0.209	4.264	<0.001
	Alcohol consumption	0.619	0.297	0.102	2.086	0.038

AopA1	Waist circumference	−0.006	0.001	−0.221	−4.423	<0.001
AopA1	Genotype	−0.067	0.028	−0.120	−2.406	0.017

ApoB	Waist circumference	0.008	0.001	0.351	7.481	<0.001
	Age	0.004	0.001	0.276	5.847	<0.001
	Glucose	−0.016	0.008	−0.097	−2.027	0.043

ApoA1/ApoB	Waist circumference	−0.020	0.003	−0.377	−7.697	<0.001
	Systolic blood pressure	−0.003	0.001	−0.168	−3.545	<0.001
	Height	0.010	0.004	0.139	2.907	0.004

Han/male
TC	Diastolic blood pressure	0.014	0.005	0.187	3.121	0.005
TC	Genotype	0.360	0.159	0.136	2.269	0.024

TG	Waist circumference	0.051	0.010	0.290	4.939	<0.001
TG	Alcohol consumption	0.380	0.165	0.135	2.302	0.022

HDL-C	Weight	−0.016	0.003	−0.299	−4.959	<0.001
HDL-C	Alcohol consumption	0.133	0.053	0.151	2.504	0.013

LDL-C	Genotype	0.372	0.119	0.186	3.136	0.002
	Body mass index	0.029	0.012	0.149	2.507	0.013
	Glucose	0.060	0.027	0.132	2.230	0.027

ApoA1	Alcohol consumption	0.193	0.030	0.368	6.383	<0.001
ApoA1	Weight	−0.008	0.002	−0.276	−4.784	<0.001

ApoB	Body mass index	0.012	0.004	0.197	3.322	0.001
	Glucose	0.028	0.008	0.199	3.426	0.001
	Diastolic blood pressure	0.003	0.001	0.159	2.681	0.008

ApoA1/ApoB	Weight	−0.019	0.003	−0.337	−5.821	<0.001
	Alcohol consumption	0.234	0.058	0.239	4.050	<0.001
	Glucose	−0.051	0.019	−0.156	−2.717	0.007

Han/female
TC	Age	0.014	0.004	0.208	3.986	<0.001
TC	Height	−0.020	0.008	−0.130	−2.505	0.013

TG	Waist circumference	0.029	0.006	0.234	4.573	<0.001
TG	Diastolic blood pressure	0.014	0.005	0.145	2.825	0.005

HDL-C	Waist circumference	−0.009	0.004	−0.184	−2.259	0.024
HDL-C	Body mass index	−0.023	0.011	−0.169	−2.077	0.039

LDL-C	Age	0.014	0.003	0.265	5.363	<0.001
LDL-C	Body mass index	0.027	0.012	0.112	2.275	0.023

ApoA1	Body mass index	−0.015	0.003	−0.220	−4.364	<0.001
ApoB	Age	0.004	0.001	0.286	5.829	<0.001
	Body mass index	0.012	0.003	0.205	4.241	<0.001
	Cigarette smoking	−0.156	0.058	−0.130	−2.663	0.008

ApoA1/ApoB	Age	−0.006	0.001	−0.209	−4.279	<0.001
	Cigarette smoking	0.413	0.133	−0.151	3.096	0.002
	Body mass index	−0.040	0.007	−0.287	−5.970	<0.001

TC: total cholesterol; TG: triglyceride; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; ApoA1: apolipoprotein A1; ApoB: apolipoprotein B; ApoA1/ApoB: the ratio of apolipoprotein A1 to apolipoprotein B; B: unstandardized coefficient; Beta: standardized coefficient. The correlation among serum lipid parameters and the genotypes and several environmental factors was determined by multivariable linear regression analyses with stepwise modeling.