Bioinformatics Analysis Identifies TNFRSF1A as a Biomarker of Liver Injury in Sepsis TNFRSF1A is a Biomarker for Septic Liver Injury
Table 1
Description of the eight hub genes among the 21 overlapping genes in GSE60088, GSE23767, and GSE71530 datasets.
No
Gene symbol
Full name
Function
1
OSMR
Oncostatin M receptor
Binds IL31 to activate STAT3 and possibly STAT1 and STAT5
2
TNFRSF1A
Tumor necrosis factor receptor superfamily, member 1a
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha
3
ICAM1
Intercellular adhesion molecule 1
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1
4
STAT3
Signal transducer and activator of transcription 3
Transcription factor that binds to the IL-6 responsive elements identified in the promoters of various acute-phase protein genes
5
CXCL1
Chemokine (C-X-C motif) ligand 1
Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation
6
NFKBIZ
Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta
Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. It is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS
7
LITAF
LPS-induced TN factor
May regulate through NFKB1 the expression of the CCL2/MCP-1 chemokine. May play a role in tumor necrosis factor alpha (TNF-alpha) gene expression
8
SAA2
Serum amyloid A 2
Major acute phase reactant. Apolipoprotein of the HDL complex
