Research Article
Bioinformatics Analysis Identifies TNFRSF1A as a Biomarker of Liver Injury in Sepsis TNFRSF1A is a Biomarker for Septic Liver Injury
Table 2
Association of the eight hub genes with infection and liver diseases (from the CTD database).
| Gene | Disease name | Disease ID | Inference score | Reference count |
| OSMR | Bacterial infections | MESH: D001424 | 11.47 | 4 | Bacteremia | MESH: D016470 | 6.67 | 5 | Chemical and drug-induced liver injury | MESH: D056486 | 181.83 | 996 | Liver diseases | MESH: D008107 | 97.81 | 80 | Liver failure, acute | MESH: D017114 | 44.32 | 190 |
| TNFRSF1A | Bacterial infections | MESH: D001424 | 12.97 | 10 | Bacteremia | MESH: D016470 | 7.65 | 7 | Staphylococcal infections | MESH: D013203 | 15.66 | 112 | Chemical and drug-induced liver injury | MESH: D056486 | 373.55 | 1473 | Liver diseases | MESH: D008107 | 173.23 | 133 | Liver failure, acute | MESH: D017114 | 105.65 | 219 |
| ICAM1 | Bacterial infections | MESH: D001424 | 38.09 | 14 | Bacteremia | MESH: D016470 | 10.32 | 8 | Immune suppression | OMIM: 146850 | 22.44 | 4 | Staphylococcal infections | MESH: D013203 | 31.17 | 123 | Chemical and drug-induced liver injury | MESH: D056486 | 624.5 | 1763 | Liver diseases | MESH: D008107 | 253.83 | 168 | Liver failure, acute | MESH: D017114 | 145.9 | 251 |
| STAT3 | Bacterial infections | MESH: D001424 | 30.62 | 14 | Immune suppression | OMIM:146850 | 9.5 | 4 | Staphylococcal infections | MESH: D013203 | 15.89 | 113 | Chemical and drug-induced liver injury | MESH: D056486 | 468.99 | 1621 | Liver diseases | MESH: D008107 | 196.71 | 155 | Liver failure, acute | MESH: D017114 | 104.56 | 220 |
| CXCL1 | Bacterial infections | MESH: D001424 | 38.75 | 13 | Bacteremia | MESH: D016470 | 19.38 | 11 | Staphylococcal infections | MESH: D013203 | 27.98 | 126 | Chemical and drug-induced liver injury | MESH: D056486 | 492.25 | 1599 | Liver diseases | MESH: D008107 | 194.1 | 160 | Liver failure, acute | MESH: D017114 | 119.02 | 237 |
| NFKBIZ | Bacterial infections | MESH: D001424 | 16.93 | 10 | Pneumococcal infections | MESH: D011008 | 11.06 | 4 | Staphylococcal infections | MESH: D013203 | 13.23 | 110 | Chemical and drug-induced liver injury | MESH: D056486 | 223.35 | 1151 | Liver diseases | MESH: D008107 | 118.82 | 94 | Liver failure, acute | MESH: D017114 | 71.4 | 189 |
| LITAF | Bacterial infections | MESH: D001424 | 20.71 | 8 | Pneumococcal infections | MESH: D011008 | 11.09 | 4 | Staphylococcal infections | MESH: D013203 | 10.05 | 99 | Chemical and drug-induced liver injury | MESH: D056486 | 269.74 | 1285 | Liver diseases | MESH: D008107 | 145.5 | 101 | Liver failure, acute | MESH: D017114 | 80.37 | 205 |
| SAA2 | Bacterial infections | MESH: D001424 | 5.71 | 2 | Candidiasis | MESH: D002177 | 7.29 | 13 | Q fever | MESH: D011778 | 9.64 | 1 | Chemical and drug-induced liver injury | MESH: D056486 | 146.38 | 987 | Liver diseases | MESH: D008107 | 96.08 | 79 | Liver failure, acute | MESH: D017114 | 36.44 | 165 |
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