Bioinformatics Analysis Identifies TNFRSF1A as a Biomarker of Liver Injury in Sepsis TNFRSF1A is a Biomarker for Septic Liver Injury

Table 2

Association of the eight hub genes with infection and liver diseases (from the CTD database).

Gene	Disease name	Disease ID	Inference score	Reference count
OSMR	Bacterial infections	MESH: D001424	11.47	4
	Bacteremia	MESH: D016470	6.67	5
	Chemical and drug-induced liver injury	MESH: D056486	181.83	996
	Liver diseases	MESH: D008107	97.81	80
	Liver failure, acute	MESH: D017114	44.32	190
TNFRSF1A	Bacterial infections	MESH: D001424	12.97	10
	Bacteremia	MESH: D016470	7.65	7
	Staphylococcal infections	MESH: D013203	15.66	112
	Chemical and drug-induced liver injury	MESH: D056486	373.55	1473
	Liver diseases	MESH: D008107	173.23	133
	Liver failure, acute	MESH: D017114	105.65	219
ICAM1	Bacterial infections	MESH: D001424	38.09	14
	Bacteremia	MESH: D016470	10.32	8
	Immune suppression	OMIM: 146850	22.44	4
	Staphylococcal infections	MESH: D013203	31.17	123
	Chemical and drug-induced liver injury	MESH: D056486	624.5	1763
	Liver diseases	MESH: D008107	253.83	168
	Liver failure, acute	MESH: D017114	145.9	251
STAT3	Bacterial infections	MESH: D001424	30.62	14
	Immune suppression	OMIM:146850	9.5	4
	Staphylococcal infections	MESH: D013203	15.89	113
	Chemical and drug-induced liver injury	MESH: D056486	468.99	1621
	Liver diseases	MESH: D008107	196.71	155
	Liver failure, acute	MESH: D017114	104.56	220
CXCL1	Bacterial infections	MESH: D001424	38.75	13
	Bacteremia	MESH: D016470	19.38	11
	Staphylococcal infections	MESH: D013203	27.98	126
	Chemical and drug-induced liver injury	MESH: D056486	492.25	1599
	Liver diseases	MESH: D008107	194.1	160
	Liver failure, acute	MESH: D017114	119.02	237
NFKBIZ	Bacterial infections	MESH: D001424	16.93	10
	Pneumococcal infections	MESH: D011008	11.06	4
	Staphylococcal infections	MESH: D013203	13.23	110
	Chemical and drug-induced liver injury	MESH: D056486	223.35	1151
	Liver diseases	MESH: D008107	118.82	94
	Liver failure, acute	MESH: D017114	71.4	189
LITAF	Bacterial infections	MESH: D001424	20.71	8
	Pneumococcal infections	MESH: D011008	11.09	4
	Staphylococcal infections	MESH: D013203	10.05	99
	Chemical and drug-induced liver injury	MESH: D056486	269.74	1285
	Liver diseases	MESH: D008107	145.5	101
	Liver failure, acute	MESH: D017114	80.37	205
SAA2	Bacterial infections	MESH: D001424	5.71	2
	Candidiasis	MESH: D002177	7.29	13
	Q fever	MESH: D011778	9.64	1
	Chemical and drug-induced liver injury	MESH: D056486	146.38	987
	Liver diseases	MESH: D008107	96.08	79
	Liver failure, acute	MESH: D017114	36.44	165